MDS
100 Oral and Maxillofacial Pathology Thesis Topics
Academic session 2026-2027 · 100 topics
This page lists 100 oral and maxillofacial pathology thesis topics for Master of Dental Surgery postgraduate students for the 2026-2027 academic session. The topics are structured around practical dissertation questions that can be adapted to the clinical workload, imaging facilities, laboratory support, materials and records available in a dental teaching institution.
The oral and maxillofacial pathology thesis topics below cover oral cancer, potentially malignant disorders, odontogenic lesions, salivary gland pathology, histopathology, special stains, immunohistochemistry, cytology, forensic applications and digital pathology. They include cross-sectional, observational, comparative, imaging-based, record-based and in-vitro approaches so that students can select a research question that matches their departmental resources while retaining a clearly measurable primary outcome.
Click any topic to open it in the protocol generator with the title already filled in.
- Clinicopathological profile of oral squamous cell carcinoma diagnosed at a tertiary dental care centre: a retrospective cross-sectional study.Get protocol
- Association between tobacco habits and clinicopathological characteristics of oral squamous cell carcinoma: an observational cross-sectional study.Get protocol
- Comparison of clinicopathological characteristics of oral squamous cell carcinoma among tobacco users and non-users: a comparative cross-sectional study.Get protocol
- Association between duration and frequency of smokeless tobacco use and histopathological grade of oral squamous cell carcinoma: a retrospective analytical study.Get protocol
- Comparison of oral squamous cell carcinoma among younger and older adult patients with respect to site, habits and histopathological characteristics: a comparative retrospective study.Get protocol
- Association between tumour differentiation and pattern of invasion in oral squamous cell carcinoma: a histopathological cross-sectional study.Get protocol
- Comparison of tumour budding among different histopathological grades of oral squamous cell carcinoma: a comparative histopathological study.Get protocol
- Assessment of tumour–stroma ratio in oral squamous cell carcinoma and its association with histopathological parameters: a cross-sectional image-analysis study.Get protocol
- Comparison of nuclear morphometric parameters among normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma: a comparative histomorphometric study.Get protocol
- Evaluation of mitotic activity among different histopathological grades of oral squamous cell carcinoma: a comparative histopathological study.Get protocol
- Clinicopathological profile of oral potentially malignant disorders diagnosed at a tertiary dental hospital: a retrospective cross-sectional study.Get protocol
- Comparison of demographic, habit and clinical characteristics of oral leukoplakia and oral submucous fibrosis: a comparative cross-sectional study.Get protocol
- Association between tobacco and areca nut habits and severity of oral epithelial dysplasia: an observational cross-sectional study.Get protocol
- Comparison of histopathological features among clinically homogeneous and non-homogeneous oral leukoplakia: a comparative study.Get protocol
- Association between clinical characteristics of leukoplakia and severity of epithelial dysplasia: a cross-sectional analytical study.Get protocol
- Histopathological spectrum of oral submucous fibrosis and its association with clinical stage: an observational cross-sectional study.Get protocol
- Comparison of epithelial thickness and connective tissue changes among different histopathological grades of oral submucous fibrosis: a comparative histomorphometric study.Get protocol
- Assessment of mast cell density among normal oral mucosa and different grades of oral submucous fibrosis: a comparative histopathological study.Get protocol
- Comparison of collagen characteristics in normal oral mucosa and oral submucous fibrosis using special staining and digital image analysis: a comparative study.Get protocol
- Association between areca nut consumption pattern and clinical severity of oral submucous fibrosis: a cross-sectional study.Get protocol
- Clinicopathological profile of odontogenic cysts diagnosed at a tertiary dental care centre: a retrospective cross-sectional study.Get protocol
- Comparison of demographic and anatomical distribution of inflammatory and developmental odontogenic cysts: a comparative record-based study.Get protocol
- Histopathological spectrum of radicular cysts and associated inflammatory changes: an observational cross-sectional study.Get protocol
- Comparison of epithelial thickness and inflammatory cell density in radicular and dentigerous cysts: a comparative histopathological study.Get protocol
- Evaluation of mast cell density in radicular cysts, dentigerous cysts and odontogenic keratocysts: a comparative histopathological study.Get protocol
- Comparison of collagen characteristics in the walls of different odontogenic cysts using special stains: a comparative histochemical study.Get protocol
- Histomorphometric comparison of epithelial lining characteristics among common odontogenic cysts: a comparative study.Get protocol
- Clinicopathological profile of odontogenic tumours diagnosed at a tertiary dental hospital: a retrospective cross-sectional study.Get protocol
- Comparison of demographic and anatomical characteristics of benign odontogenic tumours: a comparative record-based study.Get protocol
- Clinicopathological and histomorphological profile of ameloblastoma: a retrospective observational study.Get protocol
- Comparison of histopathological characteristics among different variants of ameloblastoma: a comparative study.Get protocol
- Association between radiographic pattern and histopathological variant of ameloblastoma: a cross-sectional analytical study.Get protocol
- Comparison of stromal characteristics among ameloblastoma and odontogenic keratocyst using histochemical stains: a comparative study.Get protocol
- Evaluation of proliferative activity in ameloblastoma and odontogenic keratocyst using immunohistochemical markers: a comparative cross-sectional study.Get protocol
- Comparison of epithelial proliferative activity among dentigerous cyst, odontogenic keratocyst and ameloblastoma: an immunohistochemical study.Get protocol
- Histopathological spectrum of calcifying odontogenic lesions diagnosed at a tertiary dental centre: a retrospective cross-sectional study.Get protocol
- Clinicopathological profile of fibro-osseous lesions of the jaws: a retrospective observational study.Get protocol
- Comparison of histomorphometric characteristics among fibrous dysplasia and ossifying fibroma: a comparative histopathological study.Get protocol
- Clinicopathological spectrum of giant cell lesions of the jaws: a retrospective cross-sectional study.Get protocol
- Comparison of multinucleated giant cell density and stromal characteristics among central and peripheral giant cell lesions: a comparative histopathological study.Get protocol
- Clinicopathological profile of salivary gland tumours diagnosed at a tertiary care centre: a retrospective cross-sectional study.Get protocol
- Comparison of demographic and histopathological characteristics of benign and malignant salivary gland tumours: a comparative study.Get protocol
- Histopathological spectrum of pleomorphic adenoma and its morphological variants: an observational cross-sectional study.Get protocol
- Comparison of cellular and stromal components among different histological patterns of pleomorphic adenoma: a histomorphometric study.Get protocol
- Evaluation of proliferative activity in selected benign and malignant salivary gland neoplasms using immunohistochemical markers: a comparative study.Get protocol
- Comparison of myoepithelial cell markers among selected salivary gland tumours: an immunohistochemical cross-sectional study.Get protocol
- Clinicopathological profile of mucoepidermoid carcinoma of salivary glands: a retrospective cross-sectional study.Get protocol
- Comparison of histopathological features among different grades of mucoepidermoid carcinoma: a comparative study.Get protocol
- Clinicopathological spectrum of non-neoplastic salivary gland lesions: a retrospective observational study.Get protocol
- Histopathological profile of oral lichen planus diagnosed at a tertiary dental hospital: a cross-sectional record-based study.Get protocol
- Comparison of epithelial and inflammatory characteristics among different clinical forms of oral lichen planus: a comparative histopathological study.Get protocol
- Comparison of mast cell density in oral lichen planus and normal oral mucosa: a comparative histopathological study.Get protocol
- Assessment of basement membrane changes in oral lichen planus using special staining techniques: a histopathological cross-sectional study.Get protocol
- Clinicopathological spectrum of vesiculobullous lesions affecting the oral cavity: a retrospective cross-sectional study.Get protocol
- Comparison of histopathological features of pemphigus vulgaris and mucous membrane pemphigoid involving oral tissues: a comparative study.Get protocol
- Clinicopathological profile of oral fungal infections diagnosed in a tertiary dental care centre: a retrospective observational study.Get protocol
- Comparison of conventional histopathological staining and special fungal staining methods for detection of Candida species in oral tissue specimens: a comparative diagnostic study.Get protocol
- Histopathological spectrum of granulomatous lesions involving oral and maxillofacial tissues: a retrospective cross-sectional study.Get protocol
- Comparison of histopathological characteristics of infectious and non-infectious oral granulomatous lesions: a comparative study.Get protocol
- Clinicopathological spectrum of reactive soft-tissue lesions of the oral cavity: a retrospective cross-sectional study.Get protocol
- Comparison of exfoliative cytological features among tobacco users and non-tobacco users: a comparative cross-sectional study.Get protocol
- Evaluation of nuclear and cytoplasmic morphometric changes in buccal mucosal cells among smokeless tobacco users: a cytomorphometric cross-sectional study.Get protocol
- Comparison of nuclear-cytoplasmic ratio among normal oral mucosa, oral potentially malignant disorders and oral squamous cell carcinoma using exfoliative cytology: a comparative study.Get protocol
- Assessment of micronucleus frequency in exfoliated buccal mucosal cells among tobacco users and non-users: a comparative cross-sectional study.Get protocol
- Association between duration of tobacco exposure and micronucleus frequency in buccal mucosal cells: an observational cross-sectional study.Get protocol
- Comparison of micronucleus frequency among smokers, smokeless tobacco users and individuals without tobacco exposure: a comparative cytological study.Get protocol
- Evaluation of cytomorphometric changes in buccal mucosal cells among individuals with diabetes mellitus and systemically healthy controls: a comparative cross-sectional study.Get protocol
- Comparison of oral epithelial cell morphology among anaemic and non-anaemic individuals using exfoliative cytology: a comparative study.Get protocol
- Diagnostic utility of exfoliative cytology for identifying dysplastic changes in clinically suspicious oral lesions: a cross-sectional diagnostic accuracy study.Get protocol
- Comparison of conventional cytology and liquid-based cytology for assessment of oral mucosal lesions: a comparative diagnostic study.Get protocol
- Comparison of hematoxylin and eosin staining and selected special stains for assessment of keratinization in oral lesions: a comparative histochemical study.Get protocol
- Evaluation of collagen fibre orientation in oral squamous cell carcinoma using picrosirius red staining and polarized microscopy: a cross-sectional histochemical study.Get protocol
- Comparison of collagen birefringence among normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma: a comparative study.Get protocol
- Evaluation of elastic fibres in selected oral mucosal lesions using special staining and digital image analysis: a comparative histochemical study.Get protocol
- Comparison of manual and digital methods for measurement of epithelial thickness in oral histopathological sections: a comparative agreement study.Get protocol
- Interobserver agreement in histopathological grading of oral epithelial dysplasia among oral pathologists: a cross-sectional agreement study.Get protocol
- Comparison of conventional microscopic and digital slide-based grading of oral epithelial dysplasia: a comparative agreement study.Get protocol
- Accuracy of digital image analysis for quantification of immunohistochemical staining compared with manual scoring: a comparative methodological study.Get protocol
- Comparison of nuclear morphometric parameters obtained using manual and computer-assisted image-analysis methods: a comparative study.Get protocol
- Assessment of reproducibility of digital histomorphometric measurements in oral pathology specimens: a cross-sectional reliability study.Get protocol
- Comparison of Ki-67 expression among normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma: an immunohistochemical study.Get protocol
- Evaluation of p53 expression across different grades of oral epithelial dysplasia: a comparative immunohistochemical study.Get protocol
- Comparison of p53 expression among oral potentially malignant disorders and oral squamous cell carcinoma: a comparative cross-sectional study.Get protocol
- Association between Ki-67 expression and histopathological grade of oral squamous cell carcinoma: an observational immunohistochemical study.Get protocol
- Comparison of E-cadherin expression among different histopathological grades of oral squamous cell carcinoma: a comparative immunohistochemical study.Get protocol
- Evaluation of epithelial-mesenchymal transition markers in oral epithelial dysplasia and oral squamous cell carcinoma: a comparative immunohistochemical study.Get protocol
- Comparison of angiogenesis markers among oral epithelial dysplasia and different grades of oral squamous cell carcinoma: a comparative study.Get protocol
- Association between tumour budding and expression of selected epithelial-mesenchymal transition markers in oral squamous cell carcinoma: a cross-sectional immunohistochemical study.Get protocol
- Evaluation of cancer-associated fibroblast markers in oral squamous cell carcinoma and their association with histopathological parameters: an observational study.Get protocol
- Comparison of inflammatory cell markers at the invasive front among different grades of oral squamous cell carcinoma: a comparative immunohistochemical study.Get protocol
- Comparison of age estimation using pulp-to-tooth area ratio on digital radiographs and chronological age among adults: a cross-sectional forensic odontological study.Get protocol
- Evaluation of accuracy of different radiographic dental age estimation methods in an Indian population: a comparative cross-sectional study.Get protocol
- Comparison of dental age and chronological age among male and female children using panoramic radiographs: a comparative imaging study.Get protocol
- Assessment of sexual dimorphism using odontometric measurements of permanent teeth in an Indian population: a cross-sectional forensic study.Get protocol
- Comparison of mandibular morphometric parameters for sex estimation using panoramic radiographs: a comparative forensic imaging study.Get protocol
- Assessment of palatal rugae patterns and their association with sex in an Indian population: a cross-sectional forensic odontological study.Get protocol
- Comparison of cheiloscopic patterns among male and female young adults: a comparative cross-sectional forensic study.Get protocol
- Accuracy of artificial intelligence-assisted classification of selected oral histopathological lesions compared with expert histopathological diagnosis: a comparative diagnostic study.Get protocol
- Comparison of artificial intelligence-assisted and manual quantification of immunohistochemical markers in oral tissue sections: a comparative methodological study.Get protocol
- Knowledge, attitudes and practices regarding digital pathology, molecular diagnostics and artificial intelligence among oral pathology postgraduate students and practitioners: a cross-sectional study.Get protocol
Choosing a Oral and Maxillofacial Pathology thesis topic
How should I choose a feasible Oral and Maxillofacial Pathology thesis topic?
Start with the cases, records, imaging facilities, laboratory methods and materials that are consistently available in your department. A feasible oral pathology thesis should have a clearly defined primary outcome and should not depend on expensive equipment or rare patients unless access is already assured. Before finalizing the protocol, review recent departmental case numbers, identify the variables that can be measured reliably, and decide whether the proposed comparison groups are realistically available. A focused question with adequate numbers is usually stronger than a technically ambitious project that cannot recruit or complete its planned measurements.
Which study designs are practical for an MDS thesis in Oral and Maxillofacial Pathology?
Cross-sectional, comparative cross-sectional, retrospective record-based, imaging-based and in-vitro designs are often practical for an MDS dissertation because they can be completed within a defined academic period. The best design depends on the research question and available resources. Clinical prevalence or association questions generally suit cross-sectional methods, existing case records can support retrospective studies, and material or technique comparisons may suit controlled in-vitro work. The protocol should specify the sampling method, primary variable, measurement technique and statistical comparison in advance rather than selecting a design solely because it appears easy to conduct.
What should be checked before finalizing a Oral and Maxillofacial Pathology dissertation protocol?
Confirm that the department can provide enough eligible observations during the proposed study period and that every major variable can be measured using a standardized method. For imaging or record-based work, review a small sample of existing records to assess completeness and consistency. For in-vitro projects, verify availability of specimens, materials, equipment and the testing method before calculating the sample size. The final protocol should clearly separate the primary objective from secondary objectives, define inclusion and exclusion criteria, identify potential confounders where relevant, and use outcomes that directly answer the stated research question.
Thesis and protocol questions
How is a thesis topic different from a thesis protocol?
The topic is the title — the question a study sets out to answer, together with the population and the design. The protocol is the full document built around it: background, review of literature, aims and objectives, inclusion and exclusion criteria, sample size calculation, methodology, statistical plan, ethics considerations, consent documents and references. A topic is agreed with a guide first; the protocol is written afterwards and submitted to the institutional ethics committee.
When does a postgraduate thesis have to be submitted?
For most Indian postgraduate programmes the protocol is submitted within the first six months of joining, and the completed thesis is submitted at least six months before the final examination. Exact deadlines are set by the university, so the departmental circular for the current session takes precedence over any general timeline.
How is sample size decided for a postgraduate thesis?
Sample size follows from the primary objective, not the other way round. A prevalence study is powered from an expected proportion and an acceptable margin of error; a comparative study is powered from the expected difference between groups, the standard deviation, alpha and desired power. The figure should then be checked against the institution's actual case load for the study period, because a statistically ideal sample that cannot be recruited in the time available is not a workable plan.
Does a thesis topic need ethics committee approval?
Yes. Every postgraduate thesis involving human participants, human data or human samples requires clearance from the institutional ethics committee before data collection begins. Approval is granted on the protocol rather than on the title, and the submission usually includes the protocol, the participant information sheet and the consent form in English and in the local language.
What makes a topic realistic for a three-year postgraduate programme?
A workable topic can be completed at a single centre, with equipment and investigations that are already available in routine practice, within roughly eighteen months of data collection. Topics that depend on external funding, specialised assays, multicentre coordination or long follow-up tend to stall. Choosing a condition the department already sees in volume matters more than choosing a novel one.
Can a thesis be published as a research paper afterwards?
Yes, and it is generally expected. A thesis is usually condensed into a paper of around three to four thousand words, restructured into the standard introduction, methods, results and discussion format, with the review of literature shortened considerably. Journals differ in their requirements, and the ethics approval number from the original thesis is normally cited in the methods section.